Zero to Ten

ASA Abstracts - Abstract
Acute Opioid Tolerance in Humans: No Evidence in Models of Acute Experimental Pain
Larry F. Chu, M.D., M.S., Martin S. Angst, M.D.
Department of Anesthesia and Pain Management, Stanford University School of Medicine, Stanford, California, United States.
Background
Rodent studies consistently have documented that opioid tolerance, i.e. the need for escalating the dose to maintain a […]

Proc9.html
These proceedings cover the entire spectrum of topics contained within the congress theme, “Pain: from Molecule to Mind”, and offer a comprehensive overview of the status of pain science and medicine today.

Hospital Research - Pain
Nice reference set on research in gender differences in pain.

Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Pain Mechanisms and the Development of Analgesics (E5)
Organizers: Tony L. Yaksh, Mitchell B. Max, James C. Eisenach, Patrick W. Mantyh and Frank Porreca
June 11 - 16, 2006 • Keystone Resort • Keystone, Colorado

Current and Emerging Issues in Cancer Pain: Research and Practice
Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships of Opioid Analgesics
Charles E. Inturrisi, Department of Pharmacology, Cornell University Medical College, and Pain Research Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021
One of the goals of current pain research is improved analgesic dosing. The intensity of the pharmacodynamic (PD) effects […]

Staff: Michael C. Rowbotham, MD Research Program
Michael C. Rowbotham, MD :
CLINICAL RESEARCH PROGRAM
The primary focus of my scholarly activities is clinical research in the pathophysiology and management of neuropathic pain. Animal models do not precisely mimic human disease. As pain in animals is always an inference, findings must be validated by human studies.

Pain Research
1. Pharmacology of Human Experimental Pain
Several specific mechanisms have been proposed for encoding nociception. We have implemented human models that are believed to reflect these mechanisms and can employ them in normal human volunteers. These models involve both experimental pain states in human volunteers and neuropathic pain states. Examples of […]

Center for Musculoskeletal Pain Research

clinical pharmacology : Prof. Geisslinger
Human pain models:
* Chemical pain: CO2-stimulation with evoked cortical potentials
* Thermal-chemical pain: Heat-Capsaicin model
* Inflammatory pain: „Freeze Lesion“, tonic-nasal pain
* Electrical pain: Sinus wave model
* Mechanical pain: blunt pressure, punctuated pain
[…]

Pharmacology: Research: Pain: Human Research
This group is led by Professors Felix Bochner, Andrew Somogyi and Jason White. We have developed experimental models for the study of pain responses in humans. These have been applied to healthy volunteers, people maintained on opioid agonist medications (methadone and buprenorphine) and people maintained on the opioid antagonist […]

History of the PCRC
The PCRC is a world leader in clinical research on the pathophysiology and management of pain. One of the first university-based clinical research units devoted to the study of neuropathic pain, the PCRC was founded in 1990 by UCSF neurologist Michael C. Rowbotham, who continues to direct the program.

Martin S. Angst - Faculty & Researcher Profiles - Stanford School of Medicine

ASA Abstracts - Abstract
Time Course of Buprenorphine Induced Analgesia and Anti-Hyperalgesia in an Experimental Human Pain Model
Wolfgang Koppert, M.D., Nicole Koerber, , Andreas Wehrfritz, , Reinhard Sittl, M.D., Juergen Schuettler, M.D.
Department of Anesthesiology, University Hospital, Erlangen, Germany.
Backgrounds: Time course studies of antihyperalgesic effects are hampered by the fact that most human experimental pain models have […]

Drug Screening and Human Pain Research